01
Redox Biology
Thiol metabolism, glutathione, reactive species and redox-dependent signaling in health and disease.
Redox Biology • Proteostasis • Metabolism • Thiol Chemistry
REDOX//LAB
University of Urbino Carlo Bo
Exploring how redox networks shape proteostasis, metabolism, inflammation and disease — from molecular mechanisms to translational strategies.
Scientific focus
Where redox and thiol chemistry meet cell biology.
Our work investigates the molecular links among thiol homeostasis, oxidative stress, proteolytic systems, cellular metabolism and inflammatory signaling.
02
Proteostasis
Proteasome, autophagy and protein quality-control remodeling under metabolic and oxidative stress.
03
Translational Biochemistry
Mechanism-driven strategies targeting redox imbalance, inflammation, infection and metabolic dysfunction.
04
Thiol Chemistry
Thiol homeostasis, cysteine and glutathione chemistry, redox-active compounds and thiol-based molecular mechanisms.
05
Animal Disease Models
Experimental models include Pahenu2 mice for phenylketonuria, Cftr-knockout mice for cystic fibrosis, dtd mice for diastrophic dysplasia and 3xTg-AD mice for Alzheimer’s disease.
Research
Mechanisms across scales.
From small-molecule chemistry to cellular pathways, animal models and disease-relevant systems.
Redox therapeutics
Thiol-based modulation of oxidative and inflammatory pathways
Studying redox-active compounds as tools to reshape cellular stress responses and disease phenotypes.
Proteostasis
Proteasome and autophagy remodeling in aging
Defining how aging and redox imbalance reshape protein quality-control networks.
Thiol chemistry
Synthetic thiol compound chemistry and toxicity
Designing and evaluating synthetic thiol compounds, from molecular reactivity to biological activity and toxicity.
Redox metabolism
Redox modulation of endothelial energy metabolism
Exploring how synthetic thiols sustain cysteine and glutathione, enhance mitochondrial ATP production and temper inflammatory signaling.
Host–pathogen
Redox chemistry at the host–pathogen interface
Investigating biofilm behavior, virulence chemistry, inflammatory signaling and antimicrobial response.
Research vision
“Redox balance is not simply a measure of oxidative stress — it is an organizing principle connecting metabolism, protein homeostasis and cellular adaptation.”
Output
Selected work.
Team
The team.
Our team works across redox biology, proteostasis, metabolism and thiol chemistry.
Team Member
Michela Bruschi, PhD
Assistant Professor RTT
Department of Biomolecular Sciences
University of Urbino Carlo Bo
Research: Redox Biology • Proteostasis • Metabolism • Thiol Chemistry
Team Member
Alessandra Fraternale, PhD
Associate Professor
Department of Biomolecular Sciences
University of Urbino Carlo Bo
Research: Redox Biology • Thiol Chemistry • Animal Models • Cell Biology
Team Member
Rita Crinelli, PhD
Associate Professor
Department of Biomolecular Sciences
University of Urbino Carlo Bo
Research: Redox Biology • Proteostasis • Western Blotting
Team Member
Francesca Monittola, PhD
Postdoctoral Fellow
Department of Biomolecular Sciences
University of Urbino Carlo Bo
Research: Redox Biology • Proteostasis • Western Blotting
Team Member
Michele Menotta, PhD
Full Professor
Department of Biomolecular Sciences
University of Urbino Carlo Bo
Research: Mass Spectrometry • Metabolism • Proteome
Team Member
Giovanni Piersanti, PhD
Full Professor
Department of Biomolecular Sciences
University of Urbino Carlo Bo
Research: Thiol Chemistry • NMR • Synthesis
Contact
Science starts with a conversation.
Michela Bruschi, PhD
Department of Biomolecular Sciences
University of Urbino Carlo Bo
Via Cà le Suore 2, Urbino (PU), Italy
michela.bruschi@uniurb.it